Glycopyrrolate and human plasma cholinesterase
نویسندگان
چکیده
منابع مشابه
Influence of ketamine on human plasma cholinesterase.
The influence of ketamine upon human plasma cholinesterase (E.C. 3.1.1.8) was determined by means of a colorimetric assay technique at 25 degrees C, pH 7.7 with butyrylthiocholine as substrate. Ketamine caused a reversible inhibition of cholinesterase (pI50= 2.75; apparent Ki=4.94X10(-4) M). The kinetic analysis of the inhibitory action revealed a mixed competitive/non-competitive type of mecha...
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Sir,—Humphrey, Downing and Brock-Utne (1980) are less than accurate in describing the destiny of expiration switched to inspiration in the Johannesburg Circuit. They vaguely refer to experimental evidence gathered "while studying a similar system"—evidence which simply does not tally with known pharmacokinetic principles. With a fresh gas inflow of 70mlkg~' min"' in a patient weighing 65 kg, th...
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Previous communications from this Laboratory have shown that the inhibition of cy-chymotrypsin by diisopropyl fluorophosphate (DFP) is a stoichiometric reaction that comprises the introduction of a single diisopropyl phosphate group into the molecule of cu-chymotrypsin, the elimination of fluorine as HF, and the production of an undenatured, crystallizable, inhibited enzyme protein (l-3). Sever...
متن کاملA new high activity plasma cholinesterase variant.
A South African Afrikaans speaking family is reported in which a new high activity plasma cholinesterase variant was found to occur in the mother and son. The variant has the same electrophoretic mobility as the "usual' enzyme, but greater heat stability. Its higher specific activity is associated with a normal number of enzyme molecules. The variant may be inherited as a dominant trait, though...
متن کاملPlasma cholinesterase deficiency in a neonate.
We report a two-day-old infant who had a period of apnoea lasting six hours following the intravenous administration of succinylcholine (Sch). The results of her plasma cholinesterase level and dibucaine number indicate a congenital absence of plasma cholinesterase (PChE) enzyme, although both parents and siblings had normal cholinesterase levels and dibucaine numbers. This is believed to be th...
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ژورنال
عنوان ژورنال: Canadian Anaesthetists’ Society Journal
سال: 1985
ISSN: 0008-2856,1496-8975
DOI: 10.1007/bf03011423